Ion exchange chromatography with improved selectivity for the separation of polypeptide monomers, aggregates and fragments by modulation of the mobile phase

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专利权人:

Hoffmann-La Roche Inc.

发明人:

Sebastian Neumann

申请号：

US15184883

公开号：

US10377793B2

申请日:

2016.06.16

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Herein is reported a method for producing a polypeptide in monomeric form comprising the following step: recovering the polypeptide in monomeric form from an ion exchange chromatography material by applying a solution comprising a non-ionic polymer and an additive.

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