Bruce A. Shapiro,Kirill A. Afonin,Mathias D. Viard,Eckart H. Bindewald,Luc Jaeger,Arti N. Santhanam
申请号：
US14358942
公开号：
US09631192B2
申请日:
2012.11.19
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re-association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.
