THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH & HUMAN SERVICES
发明人:
SHAPIRO, BRUCE ALLEN,AFONIN, KIRILL ANDREEVICH,VIARD, MATHIAS DENIS,BINDEWALD, ECKART H.U.
申请号：
CA2856117
公开号：
CA2856117A1
申请日:
2012.11.19
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re- association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.
