PAPADOPOULOS NICHOLAS J,MURPHY ANDREW J,THURSTON GAVIN,IOFFE ELLA,BUROVA ELENA
申请号：
IN201637027641
公开号：
IN201637027641A
申请日:
2016.08.12
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention provides antibodies that bind to the T cell co inhibitor ligand programmed death ligandl (PD L1 ) protein and methods of use. In various embodiments of the invention the antibodies are fully human antibodies that bind to PD L1. In certain embodiments the present invention provides multi specific antigen binding molecules comprising a first binding specificity that binds to PD L1 and a second binding specificity that binds to a tumor cell antigen an infected cell specific antigen or a T cell co inhibitor. In some embodiments the antibodies of the invention are useful for inhibiting or neutralizing PD L1 activity thus providing a means of treating a disease or disorder such as cancer or viral infection.
