The present invention relates to a method for preparing (4R,6S)-(E)-6-[2-(2-cyclopropyl)-4-(4-Fluorophenyl)quinoline-3-yl]-vinyl-2,2-dimethyl-1,3-dioxane-4-yl]acetic acid ester derivative, which is an intermediate of pitavastatin or of the salt thereof, into a crystalline solid form. In addition, the present invention relates to a novel solvate of the intermediate and to a method for preparing pitavastatin or the salt thereof using the intermediate.La présente invention concerne un procédé de préparation dun dérivé ester de lacide (4R,6S)-(E)-6-[2-(2-cyclopropyl)-4-(4-fluorophényl)quinoléin-3- yl]vinyl-2,2-diméthyl-1,3-dioxane-4-yl]acétique, un intermédiaire de la pitavastatine, ou de son sel sous une forme cristalline solide. Linvention concerne en outre un nouveau solvate de lintermédiaire, ainsi quun procédé de préparation de pitavastatine ou de son sel en utilisant ledit intermédiaire.본 발명은 피타바스타틴 또는 그의 염의 중간체인 (4R,6S)-(E)-6-[2-(2-시클로프로필)-4-(4-플루오로페닐)퀴놀린-3-일)-비닐-2,2-디메틸-1,3-디옥산-4-일]아세트산 에스테르 유도체를 고체 결정형 형태로 제조하는 방법을 제공한다. 또한, 본 발명은 상기 중간체의 신규의 용매화물 및 상기 중간체를 사용한 피타바스타틴 또는 그의 염의 제조방법을 제공한다.
