THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;The Texas A&;M University System
发明人:
Lisa Bielke,Sherryll Layton,Billy Hargis,Neil R. Pumford,Olivia B. Faulkner,Luc Berghman,Daad Abi-Ghanem
申请号:
US14776986
公开号:
US10376571B2
申请日:
2014.03.14
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.