Michael K. Riscoe,Jane X. Kelly,Rolf W. Winter,David J. Hinrichs,Martin J. Smilkstein,Aaron Nilsen
申请号：
US13153347
公开号：
US20120010237A1
申请日:
2011.06.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A method for inhibiting a parasitic or infectious disease in a subject, wherein the parasitic or infectious disease is selected from one caused by Eimeria sp., Babesia sp., Theileria sp. or Neospora caninum, the method comprising administering to the subject a therapeutically effective amount of a compound of formula I:or formula II:or a pharmaceutically acceptable salt of formula I or formula II, wherein: R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl R2 is methyl, haloalkyl, or heteroaryl R4 is hydroxyl, carbonyloxy, or carbonyldioxy R3 is aliphatic, aryl, aralkyl, or alkylaryl and R5, R6, R7 and R8 are each individually H, halogen, alkoxy, alkyl, haloalkyl, aryl, nitro, cyano, amino, amido, acyl, carboxyl, substituted carboxyl, or —SO2R10, wherein R10 is H, alkyl, amino or haloalkyl provided that in formula I, R5 and R7 are not H or R6 is not H or methoxy and in formula II that if R4 is carbonyldioxy then R7 is not methoxy.
