PROBLEM TO BE SOLVED: To provide a pharmaceutical combination useful for indications for opioid use, such as pains due to various causes of disease.SOLUTION: This invention relates to a pharmaceutical combination of opioid and a prostaglandin compound.【課題】オピオイド使用の適応症、例えば様々な病因による痛みに有用な医薬的組み合わせの提供。【解決手段】オピオイド及びプロスタグランジン化合物の医薬的組み合わせ。【選択図】なし