vaccine composition, and use of the same

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专利权人:

CENTRO DE INMUNOLOGIA MOLECULAR

发明人:

Amelia Gutiérrez Pérez,Arianna Yglesias Rivera,Belinda Sánchez Ramírez,Narjara González Suárez

申请号：

BR112016002174

公开号：

BR112016002174A2

申请日:

2014.08.01

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “vaccine composition” is a given description of vaccine compositions that combine, in equal proportions, the extracellular growth factor receptor domains her1 and her2 or fragments thereof and, in addition, very small proteoliposomes derived from neisseria meningitidis and ganglioside gm3 (gm3-vssp) outer membrane proteins, which are intended for subcutaneous administration. The disclosed compositions allow antibodies to be induced for the treatment of malignant tumors and offer advantages because they successfully completely eliminate tumor mass and prevent tumor regression from the emergence of resistant variants.1 / 1 resumo “composiã‡ãƒo de vacinaâ€� uma descriã§ã£o ã© dada de composiã§ãµes de vacina que combinam, em proporã§ãµes iguais, os domã­nios extracelulares de receptores do fator de crescimento her1 e her2 ou fragmentos dos mesmos e, alã©m disso, proteolipossomas de tamanho muito pequeno derivados de proteã­nas de membrana externa de neisseria meningitidis e gangliosã­deo gm3 (gm3- vssp), que sã£o destinados para administraã§ã£o subcutã¢nea. as composiã§ãµes descritas permitem que anticorpos sejam induzidos para o tratamento de tumores malignos e oferecem vantagens devido ao fator de que eles eliminam com sucesso totalmente a massa do tumor e evitam a regressã£o do tumor a partir do aparecimento de variantes resistentes.

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