二價疫苗組成物及彼於腫瘤治療上之用途农业专利-农业专业知识服务系统

发明人:: SANCHEZ RAMIREZ, BELINDA,桑乔斯拉米瑞兹　布琳达,桑喬斯拉米瑞茲　布琳達,YGLESIAS RIVERA, ARIANNA,伊格里西亚斯李维拉　亚里安娜,伊格里西亞斯李維拉　亞里安娜,GUTIERREZ PEREZ, AMELIA,古提瑞兹皮瑞兹　爱蜜莉亚,古提瑞茲皮瑞茲　愛蜜莉亞,GONZALEZ SUAREZ, NARJARA,冈萨列兹苏瓦兹　纳加拉,岡薩列茲蘇瓦茲　納,桑乔斯拉米瑞兹布琳达,桑喬斯拉米瑞茲布琳達,伊格里西亚斯李维拉亚里安娜,伊格里西亞斯李維拉亞里安娜,古提瑞兹皮瑞兹爱蜜莉亚,古提瑞茲皮瑞茲愛蜜莉亞,冈萨列兹苏瓦兹纳加拉,岡薩列茲蘇瓦茲納

摘要：: The invention describes vaccine compositions combined in the same proportion with the extracellular domains of growth factor receptors Her1 and Her2 or fragments thereof and furthermore very small size proteoliposomes derived from proteins of the outer membrane of Neisseria meningitidis and GM3 ganglioside (VSSP- GM3), administered subcutaneously. The disclosed compositions, which induce the production of antibodies are used for the treatment of malignancies and offer advantages because they completely remove the tumor mass thus preventing tumor regression due to the emergence of resistant variants.本發明描述經由皮下投予之疫苗組成物，該疫苗組成物具有以相同比例組合之生長因子受體Her1和Her2之胞外結構域或彼等之片段及源自腦膜炎奈瑟氏球菌(Neisseria meningitidis)之外膜蛋白和GM3神經節苷脂的非常小尺寸之蛋白脂質體(VSSP-GM3)。本發明所揭示之誘導抗體製造的組成物係用於治療惡性腫瘤並提供益處，因該抗體完全去除腫瘤塊，從而防止因抗性變體的出現所造成之腫瘤消退。