A method of producing a population of differentiated cells comprising: a) inducingdifferentiation in a first population of cells by applying an inducer to saidcells, b) harvesting microvesicles produced from first population of cells,and c) inducing differentiation in a second population of cells by applying saidmicrovesicles or a derivative thereof to said second population of cells wherein,said first population of cells is autologous to said second population of cellsand wherein the inducer applied to said first population of cells is not presentin said second population of cells or is only present in trace amounts. Also relatedmethods of producing microvesicles, methods of medical and/or cosmetic treatmentand related products and uses.
