VERMEIJ, PAUL,KETS, EDWIN,DIRKS, CHRIS,PIEST, MARTIN
申请号：
CA3084450
公开号：
CA3084450A1
申请日:
2018.12.21
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention describes a liquid vaccine composition of a live enveloped virus and a pharmaceutically acceptable carrier, whereby the carrier is a natural deep-eutectic solvent (NADES), and the vaccine has a water activity of less than about 0.8. The NADES provides a stabilisation of the sensitive virus for prolonged time and at ambient temperature. In general, the liquid vaccine compositions according to the invention, in different compositions for the various enveloped viruses, show remarkable capabilities of stabilisation. This overcomes the need for lyophilisation, a great economic benefit. Also the liquid nature of the vaccines facilitates administration to human or animal targets.
