Tokyo Institute of Technology;Nissan Chemical Corporation
发明人:
申请号：
EP17753309.8
公开号：
EP3418289A4
申请日:
2017.02.17
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Provided is an artificial nucleoside or an artificial nucleotide which can constitute an artificial oligonucleotide having excellent nuclease resistance. An artificial nucleoside or an artificial nucleotide, which is a compound represented by formula (I) and a salt thereof. (Bx represents a pyrimidine base or a purine base； R 1 , R 2 , R 3 and R 4 independently represent a hydrogen atom, a C1-6 alkyl group or the like； Y represents NR 5 R 6 (wherein R 5 and R 6 independently represent a hydrogen atom, a C1-6 alkyl group or the like, or R 5 and R 6 , in conjunction with a nitrogen atom to which R 5 and R 6 are bound, together form a 3- to 11-membered nitrogenated non-aromatic heterocyclic ring), or a C2-9 aromatic heterocyclic group which may be substituted)； Z 1 and Z 2 independently represent a hydrogen atom, a protecting group for a hydroxy group, a phosphorus-containing group or the like； and n represents an integer of 1 to 3.)
