abstract the present invention provides, among other things, methods and compositions for production of recombinant i2s protein with improved potency and activity using i2s and fge protein co-expression cells. in some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant i2s and fge proteins. cells according to the invention are adaptable to various cell culture conditions. in some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture. "cells to produce recombinant iduronate-2-sulfatase" The present invention provides, among other things, methods and compositions for producing recombinant i2s protein with enhanced potency and activity using cells that coexpress i2s and fge protein. In some embodiments, cells according to the present invention are engineered to simultaneously overexpress recombinant β1 and β1 proteins. The cells according to the invention are adaptable to various cell culture conditions. In some embodiments, the cells of the present invention are adaptable to a large-scale suspension serum free culture.abstract the present invention provides, among other things, methods and compositions for production of recombinant i2s protein with improved potency and activity using cells co-express i2s and fge protein. in some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant i2s and fge proteins. cells according to the invention are adaptable to various cell culture conditions. in some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture. tradução do resumo resumo "células para produzir iduronato-2-sulfatase recombinante" a presente invenção fornece, entre outras coisas, métodos e composições para produção de proteína i2s recombinante com potência e atividade melhoradas usando células que coexpressam proteína i2s e fge. em algumas modalidades, as cél
