Cells for producing recombinant iduronate-2-sulfatase

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专利权人:

Inc.;Shire Human Genetic Therapies

发明人:

Boldog, Ferenc,Heartlein, Michael

申请号：

AU2013282400

公开号：

AU2013282400B2

申请日:

2013.06.28

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co- express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant I2S and FGE proteins. Cells according to the invention are adaptable to various cell culture conditions. In some embodiments, cells of the present invention adaptable to a large-scale suspension serum- free culture.

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中国工程科技知识中心

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http://www.ckcest.cn/home/