Temple University - of Commonwealth System of Higher Eduction
发明人:
Pamela C. Roehm,Kamel Khalili,Sayed Masoud Shekarabi,Hassen Wollebo
申请号：
US15543027
公开号：
US20180000970A1
申请日:
2016.01.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to compositions and methods for the inhibition of the infectivity of a herpesvirus. In certain embodiments, the compositions and methods provide a CRISPR-associated peptide and a guide nucleic acid, which induce the mutation of herpesvirus genome, thereby inhibiting the infectivity of the herpesvirus. Further disclosed are Cas peptides including Cas9 or a variant thereof comprising one or more point mutations relative to wildtype Streptococcus pyogenes Cas 9 (spCas9), and Cpf1 or a variant thereof.
