RNA guided eradication of herpes simplex type I and other related herpesviruses

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专利权人:

Temple University-of The Commonwealth System of Higher Education

发明人:

Roehm, Pamela C.,Khalili, Kamel,Shekarabi, Sayed Masoud,Wollebo, Hassen

申请号：

AU2016206692

公开号：

AU2016206692A1

申请日:

2016.01.14

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

The present invention relates to compositions and methods for the inhibition of the infectivity of a herpesvirus.The compositions and methods provide a CRISPR-associated (Cas) peptide and a guide nucleic acid, which induce the mutation of herpesvirus genome, thereby inhibiting the infectivity of the herpesvirus. Further disclosed are Cas peptides including Cas9 or a variant thereof comprising one or more point mutations relative to wildtype Streptococcus pyogenes Cas9 (spCas9), and Cpfl or a variant thereof.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/