ECOLE NORMALE SUPERIEURE;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI;THE TRUSTEES OF PRINCETON UNIVERSITY
发明人:
Benjamin GREENBAUM,Nina BHARDWAJ,Arnold LEVINE,Remi MONASSON,Simona COCCO
申请号：
US15550548
公开号：
US20180036334A1
申请日:
2016.02.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a composition comprising an isolated, single stranded RNA molecule having a nucleotide sequence comprising 20 or more bases and a pattern of CpG dinucleotides defined by a strength of statistical bias greater than or equal to zero, and a pharmaceutically acceptable carrier suitable for injection. The present invention also relates to a kit comprising a cancer vaccine and the composition of the present invention as an adjuvant to the cancer vaccine. The present invention further relates to a method of treating a subject for a tumor and a method of stimulating an immune response.
