An agent for suppressing or reducing amyloid beta (Aβ) -induced damage in the hippocampus, which comprises an extract of inflamed tissue inoculated with vaccinia virus. Also, use of an extract from inflamed tissue inoculated with vaccinia virus in the manufacture of a suppressant or reducer for Aβ-induced damage in the hippocampus.ワクシニアウイルス接種炎症組織抽出物を含有する海馬におけるアミロイドベータ(Aβ)誘導性損傷の抑制剤又は軽減剤。また、海馬におけるAβ誘導性損傷の抑制又は軽減剤の製造におけるワクシニアウイルス接種炎症組織抽出物の使用。