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A Medicine characterized by combining a Cap dependent endonuclease inhibitor of influenza virus and anti influenza patients
专利权人:
LTD.;SHIONOGI & CO.
发明人:
KITANO, Mitsutaka,YAMAMOTO, Atsuko,SHISHIDO, Takao,NOSHI, Takeshi
申请号:
CR20180356
公开号:
CR20180356A
申请日:
2016.12.14
申请国别(地区):
CR
年份:
2018
代理人:
摘要:
1. A drug, characterized by (a) a compound represented by a formula (I): a salt or solution acceptable to the drug, wherein P is hydrogen or a group of samples to be formed; a 1 is cr1ar1b, s or O; A2 is cr2ar2b, s or O; A3 is cr3ar3b, s or O; A4 is independent cr4ar4b, s or O; The number of heteroatoms of ring atoms composed of nitrogen atoms near A1, A2, A3, A4, A1 and carbon atoms near A4 is 1 or 2, respectively; R1a and r1b are independent hydrogen, halogen, tar or similar substances; R2A and r2b are independent hydrogen, halogen, tar, Or similar;R3a and R3b are independent hydrogen, halogen, tar or similar substances; R4A is independent hydrogen, halogen, tar or similar substances; r4b is independent hydrogen, halogen, tar or similar substances; R3a and R3b can be combined with adjacent carbon atoms to form aromatic or odor free carbon; n is an integer from 1 to 2; R1 is or similar to combination (b) with anti epidemic activity, You can treat or prevent influenza with acceptable salt or solution on the drug and / or antibody with anti influenza activity.Un medicamento caracterizado en que (A) un compuesto representado por la fórmula (I): su sal farmacéuticamente aceptable, o un solvato del mismo, en donde P es hidrógeno o un grupo para formar un profármaco; A1 es CR1AR1B, S u O; A2 es CR2AR2B, S u O; A3 es CR3AR3B, S u O; A4 es cada uno independientemente CR4AR4B, S u O; el número de heteroátomos entre los átomos constituyentes del anillo que consiste de A1, A2, A3, A4, átomo de nitrógeno adyacente a A1 y átomo de carbono adyacente a A4 es 1 o 2; R1A y R1B son cada uno independientemente hidrógeno, halógeno, alquilo o similares; R2A y R2B son cada uno independientemente hidrógeno, halógeno, alquilo, o similares; R3A y R3B son cada uno independientemente hidrógeno, halógeno, alquilo, o similares; R4A es cada uno independientemente hidrógeno, halógeno, alquilo, o similares; R4B es cada uno independientemente hidrógeno, halógeno, alquilo, o similares; R3A y R3B pu
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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