INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YONSEI UNIVERSITY
发明人:
CHEON, JIN WOO,CHOI, JIN-SIL,YOO, JEONGSOO,PARK, JEONG CHAN,CHANG, YONGMIN
申请号：
EP09742870
公开号：
EP2285422A4
申请日:
2009.05.08
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention relates a dual-modality PET (positron emission tomography)/MRI (magnetic resonance imaging) contrast agent, a hybrid nanoparticle comprising: (a) a magnetic signal generating core (b) a water-soluble multi-functional ligand coated on the signal generating core and (c) a positron emitting factor linked to the water-soluble multi-functional ligand. The contrast agent of the present invention is the dual-modality contrast agent enabling to perform PET and MR imaging and can effectively obtain images having the merits of PET (excellent sensitivity and high temporal resolution) and MR (high spatial resolution and anatomical information) imaging. The contrast agent of the present invention is very useful for non-invasive and highly sensitive real-time fault-free imaging of various biological events such as cell migration, diagnosis of various diseases (e.g., cancer diagnosis) and drug delivery.
