The present invention relates to one kind for generating radiotherapy disposition plan (33 34) system to dispose the object construction in patient body. The system comprises: (i) modeling unit is configured as the model to change with time based on the profile for quantifying the object construction to determine a series of estimation (31a-d of the profile for the continuous time point during radiation therapy disposition 32a-d) And (ii) planning unit, it is configured as the series estimation (31a-d of the profile based on the object construction 32a-d) determine the disposition plan (33 34). In addition, the present invention relates to the methods executed in the system.
