Murphy, Andrew J.,Thurston, O. Gavin,Varghese, Bindu,Gurer, Cagan
申请号：
AU2014321187
公开号：
AU2014321187A1
申请日:
2014.09.23
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.
