Andrew J. Murphy,O. Gavin Thurston,Bindu Varghese,Cagan Gurer
申请号：
US14882531
公开号：
US09462794B2
申请日:
2015.10.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.
