Baylor Research Institute;The Rockefeller University
发明人:
Banchereau, Jacques F.,Palucka, Anna Karolina,Fay, Joseph,Steinman, Ralph,Dhodapkar, Madhav,Wittkowski, Knut M.
申请号：
AU2010235902
公开号：
AU2010235902B2
申请日:
2010.10.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010235902B220120119.pdf#####ABSTRACT A method of treating malignancies through induction of immune responses has been found. In one aspect, the present invention is a method for treating malignancy comprising administering an effective amount of a vaccine comprising antigen-presenting cells loaded with at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides. In another embodiment, the vaccine comprises at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides which target antigen-presenting cells in the patient. The vaccines can also further comprise antigen-presenting cells loaded with control antigens used to determine the patient's immune competence. The evaluation of vaccine-induced immune responses in blood provides a predictive factor for treatment efficacy.
