ГАРДЕЛЛА Томас Дж. (US),ПОТТС Джон Т. (US),ДЖАППНЕР Харальд (US),ОКАДЗАКИ Макото (JP)
申请号：
RU2012153768/10
公开号：
RU2012153768A
申请日:
2011.05.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The polypeptide or its pharmaceutically acceptable salt containing the formula (I): X-Val-X-Glu-Ile-Gln-Leu-X-His-XXXXXXXXX-Arg-Arg-Arg-X-Phe-Leu-XX-Leu -Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile (I) X is Ser, Ala or Aib； X is Ser, Ala or Aib； X is Met, Leu or Nle； X is Asn, Ala , Val, Asp, Glu or Gln； X is Leu, Ala, Val, Met, Lys, Ile, Arg, Har or Trp； X is Gly, Ala, His or Arg； X is Lys, Ala, Leu, Gln, Arg , His or Trp； X is His, Leu, Arg, Phe, Trp or Ser； X is Ile or Leu； X is Gln or Asn； X is Asp or Ser； X is Ala, Leu, Met, Glu, Ser or Phe； X is Ala, Phe, Glu, Ser, Leu, Asn, Trp or Lys； X is His, Arg, Leu, Trp or Lys and X is Lys, His, Ala, Ser, Asn or Arg ； or a fragment thereof containing amino acids 1-28, 1-29, 1-30, 1-31, 1-32, 1-33, 1-34, or 1-35 of formula (I), provided that at least one of Xне is Leu or Met, Xне is Phe and Xне is His.2. The polypeptide or its pharmaceutically acceptable salt according to claim 1, where the specified polypeptide contains the formula (II): X-Val-X-Glu-Ile-Gln-Leu-X-His-XXX-Lys-XXXXX-Arg-Arg-Arg- X-Phe-Leu-His-X-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile (II) X is Ser, Ala or Aib； X is Ser, Ala or Aib； X is Met, Leu or Nle； X is Asn, Gln or Asp； X is Leu, Arg, Har or Lys； X is Gly or Ala； X is His, Trp or Ser； X is Ile or Leu； X is Gln or Asn； X is Asp or Ser； X is Ala or Leu； X is Ala or Phe and X is oboj Lys or His； or a fragment thereof comprising amino acids 1-28, 1-29, 1-30, 1-31, 1-32, 1-33, 1-34 or 1-35 of formula (II) .3. The polypeptide or its pharmaceutically acceptable salt according to claim 2, containing the formula (III): X-Val-X-Glu-Ile-Gln-Leu-X-His-X-X-X-Lys-X-Ile-X-1. Полипептид или его фармацевтически приемлемая соль, содержащие формулу (I):X-Val-X-Glu-Ile-Gln-Leu-X-His-X-X-X-X-X-X-X-X-X-Arg-Arg-Arg-X-Phe-Leu-X-X-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile(I)Xпредставляет собой Ser, Ala или Aib；Xпредставляет собой Ser, Ala или Aib；Xпредставляет собой Met, Leu или Nle；Xпредставляет собой Asn, Ala, Val, Asp, Glu или G
