医薬のためのプラットフォームとしての、少なくとも1つの保護されたチオール領域を有するPEG-アルブミン組成物
- 专利权人:
- ザ・ユニバーシティ・オブ・トレド
- 发明人:
- アサリー,ラゲブ,ディグマン,ジョン デイビッド,シャピロ,ジョセフ アイ.
- 申请号:
- JP2012503428
- 公开号:
- JP2012522782A
- 申请日:
- 2010.04.02
- 申请国别(地区):
- JP
- 年份:
- 2012
- 代理人:
- 摘要:
- This composition comprises a polyethylene glycol-albumin composition having at least one protected thiol region wherein the composition comprises PEG-AlbCys34 with Cys-34 preserved as a thiol. The albumin is linked to medications such as, antioxidants with a reduced sulfhydryl group through the Cys 34 residing on the albumin. The compositions are useful in treating patients.本組成物は、少なくとも1つの保護されたチオール領域を有するポリエチレングリコール-アルブミン組成物を含み、前記組成物はCys-34がチオールとして保存されたPEG-AlbCys-34を含む。前記アルブミンは、アルブミン上に存在するCys-34を介して、還元されたスルフヒドリル基により、抗酸化剤などの医薬と結合される。この組成物は、患者の治療に有用である。
- 来源网站:
- 中国工程科技知识中心
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