Substituted bicyclic pyrimidone derivatives

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专利权人:

Franck Slowinski;Nathalie Chereze;Alistair Lochead;Mourad Saady;Philippe Yaiche

发明人:

Nathalie Chereze,Alistair Lochead,Mourad Saady,Franck Slowinski,Philippe Yaiche

申请号：

US12122111

公开号：

US08148364B2

申请日:

2008.05.16

申请国别(地区):

US

年份:

2012

代理人:

摘要：

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof:Wherein Y, Z, R1, R2, R3, R4, R5, R6, R7, n, m, and o are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.

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