The present invention, a decrease in fat cells and the anti-obesity effect leading the reduction of fat cells due to the increase in the osteoblastic cells, osteoblasts increased the lead bone disease and fractures of the effects of, and, complementary fat in mesenchymal stem cells A relates to extracts of thoroughwort genus with a prevention effect of the cells decrease and osteoporosis due to an increase in osteoblastic cells, and stem extract of thoroughwort genus were collected monthly, thoroughwort genus of stem taken in September DCM fraction layer of the extract, PPAR is an important factor of fat cell differentiation in pluripotent stem a cell line C3H10T1 / 2 cells and Primary mesenchymal stem cells, AP2, CD36, adiponectin C / EBP, the LPL activity and inhibit, ALP is an important factor for osteoblast differentiation, osterix, increased the activity of COlI, RUNX2. In osteoporosis animal model experiments using ovariectomized, it shows the effect of increase and decrease of the fat cells in the bone marrow of the bone mineral density (BMD), and is utilized as a useful substance for the prevention and treatment of osteoporosis Ur.BACKGROUND 28.本発明は、脂肪細胞の減少及び造骨細胞の増加による脂肪細胞の減少を通じる抗肥満効果と、造骨細胞の増加を通じる骨疾患や骨折の効果、そして、間葉幹細胞で相補的な脂肪細胞の減少及び造骨細胞の増加による骨多孔症の予防效果を有するフジバカマ属の抽出物に関するものであって、月別に採取したフジバカマ属の茎抽出物と、9月に採取したフジバカマ属の茎抽出物とのDCM fraction層は、多能性幹細胞株であるC3H10T1/2細胞とPrimary mesenchymal stem細胞とで脂肪細胞分化の重要な因子であるPPARγ、AP2、CD36、adiponectin C/EBPα、LPL活性を阻害し、造骨細胞分化の重要な因子であるALP、osterix、COlI、RUNX2の活性を増加させた。卵巣切除を利用した骨多孔症動物モデル実験では、骨密度(BMD)の増加と骨髄内の脂肪細胞の減少という効果を示しており、骨多孔症の予防と治療とに有用な物質として利用されうる。【選択図】図28
