您的位置: 首页 > 农业专利 > 详情页

FORMULATION, PROCEDE ET COMPOSITION POUR THERAPIE CELLULAIRE
专利权人:
Immunovative Therapies; Ltd.
发明人:
申请号:
EP05724065.7
公开号:
EP1749090B1
申请日:
2005.03.01
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
A composition is described that comprises a treatment effective amount of cells, of which a portion are T-cells, wherein the T-cells have been harvested from cell culture and are thereby removed from activating stimuli in the culture and the harvested T-cells are formulated for infusion by a method comprising (1) contacting the T-cells with one or more agents that ligate a cell surface moiety on at least a portion of the T-cells, (2) cross-linking the one or more agents with biodegradable nanospheres or microspheres coated with a material capable of cross-linking the one or more agents, (3) suspending the T-cells, the one or more agents and the coated biodegradable nanospheres or microspheres in an infusion medium, and (4) packaging in a suitable container, wherein the T-cells are in an activated state in the medium, wherein the one or more agents are mouse-derived monoclonal antibodies, or fragments or genetically engineered derivatives thereof, and the material coating the nanospheres or microspheres is goat or sheep anti-mouse polyclonal antibodies. Methods for the preparation of the composition are also described.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充