VOET PIERRE,DALEMANS WILFRIED L J,THONNARD JOELLE,DEQUESNE GUY,LOBET YVES,POOLMAN JAN,BERTHET FRANCOIS-XAVIER JACQUES,DENOEL PHILIPPE,FERON CHRISTIANE,THIRY GEORGES
申请号：
NO20020506
公开号：
NO332230B1
申请日:
2002.01.31
申请国别(地区):
NO
年份:
2012
代理人:
摘要：
Preparation in a vial from a Gram negative bacterial Strain Genetically Modified - wherein the preparation can be obtained using one or more processes.The following ccionados Group: (a) a process of reduction of the variable or the immunodominant antigens not Protectors in the preparation of the bulb, which comprises the steps of determining LIdentity of the Antigen.Genetically modifying a bacterial Strain so that it partially or completely interrupt a promoter Sequence Chain up a gene encoding the Antigen for the GIn is expressed at a Lower level than in the vial is not amended,Ampoules and the aforementioned Strain； (b) a process of OMP on Regulation of Protective Antigen in the preparation of the bulb comprising the steps of identifying these ant u00edgenos,By genetically modifying a bacterial Strain so to introduce a more powerful Chain Promoter Sequence upstream of a gene encoding the Antigen to which the Gene is expressed in aHigher Level ALDE Ampoule not modifiedAmpoules and the aforementioned strain: (c) process on regulating the expression of OMP antigens Protective conditionally expressed in the preparation of the vial to COmprende the steps of identifying the antigen, a bacterial Strain of genetically modified to eliminate repressive Mechanisms controlling their expression,Chain up a gene encoding the AntigenAmpoules and the aforementioned Strain； (d) a process of Modification of the Lipid portion of bacterial LPS in the Interior of the preparation of the vial,Comprising the steps of identifying the Gene implicated in Toxic Lipid portion to the back of the LPS.A bacterial Strain of genetically modified so as to reduce or clear the expression of that Gene.And make Ampoules that Strain； (e) a process for modifying the Lipid portion of bacterial LPS in the preparation of the vial,Comprising the steps of identifying the Gene involved in doing less toxic to the Lipid portion of the LPS.Den foreliggende oppfinnelsen angår en immunbeskyttende og ikke-toksisk gra
