PROCEDE ET COMPOSITIONS PERMETTANT L'INDUCTION D'UNE DIFFERENCIATION DES CELLULES MYELOIDES SUPPRESSIVES POUR TRAITER LE CANCER ET LES MALADIES INFECTIEUSES

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专利权人:

OSE IMMUNOTHERAPEUTICS

发明人:

POIRIER, NICOLAS,VANHOVE, BERNARD

申请号：

CA2964203

公开号：

CA2964203A1

申请日:

2015.10.21

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present invention pertains to the field of immunotherapy. More specifically, the present invention provides a method for differentiating myeloid-derived suppressor cells (MDSC) into non suppressive cells, by administering a compound blocking the interaction between SIRPa and CD47 to a patient in need thereof, in order to reduce MDSC-induced immunodepression and consequently allow appropriate immune responses in cancers, infectious diseases, vaccination,, trauma, autoimmune diseases, chronic inflammatory diseases and transplantation.

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