CORKEY BRITTON KENNETH,ELZEIN ELFATIH,JIANG ROBERT H,KALLA RAO V,KOLTUN DMITRY,LI XIAOFEN,MARTINEZ RUBEN,PARKHILL ERIC Q,PERRY THAO,ZABLOCKI JEFF,VENKATARAMANI CHANDRASEKAR,GRAUPE MICHAEL,GUERRERO JUA
申请号:
IN10490/DELNP/2013
公开号:
IN2013DN10490A
申请日:
2013.12.05
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I : wherein Z1, Z2, Z3, Z4, X, Y, R2 R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.