ERBB-2 TARGETING AGENT AND A BISPECIFIC ANTIBODY WITH ANTIGEN-BINDING SITES THAT BIND AN EPITOPE ON AN EXTRACELLULAR PART OF ERB-2 AND ERBB-3, FOR TREATMENT OF AN INDIVIDUAL WITH AN ERBB-2, ERBB-2/ERBB-3 POSITIVE TUMOUR
THROSBY, Mark,GEUIJEN, Cecilia Anna Wilhelmina,MAUSSANG-DETAILLE, David Andre Baptiste,LOGTENBERG, Ton
申请号：
PH12019550203
公开号：
PH12019550203A1
申请日:
2019.09.27
申请国别(地区):
PH
年份:
2020
代理人:
摘要：
The invention relates among others to antibodies comprising a first antigen- binding site that binds ErbB-2 and a second antigen-binding site that binds ErbB- 3. The antibodies can typically reduce a ligand-induced receptor function of ErbB-3 on a ErbB-2 and ErbB-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an ErbB-2, ErbB-3 or ErbB-2/3 positive tumor.
