ErbB-2 targeting agent and a bispecific antibody with antigen-binding sites that bind an epitope on an extracellular part of erb-2 and erbB-3, for treatment of an individual with an erbB-2, erbB-2/erbB-3 positive tumour
Throsby, Mark,Geuijen, Cecilia Anna Wilhelmina,Maussang-Detaille, David Andre Baptiste,Logtenberg, Ton
申请号：
AU2018246872
公开号：
AU2018246872A1
申请日:
2018.04.03
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The invention relates among others to antibodies comprising a first antigen- binding site that binds ErbB-2 and a second antigen-binding site that binds ErbB- 3. The antibodies can typically reduce a ligand-induced receptor function of ErbB-3 on a ErbB-2 and ErbB-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an ErbB-2, ErbB-3 or ErbB-2/3 positive tumor.
