PROBLEM TO BE SOLVED: To provide a new pancreatic islet cell protective agent which inhibits disorders in the taking of the pancreatic islet and the transplantation of the pancreatic islet upon the transplantation of the pancreatic islet in the treatment of diabetes, and can improve the taking of the pancreatic islet, and a method for inhibiting the disorders of pancreatic islet cells after the transplantation of the pancreatic islet including a process of adding the pancreatic islet cell protective agent to the pancreas of a donor or the pancreatic islet taken from the donor and transplanting the pancreatic islet after the addition to a diabetic patient.SOLUTION: The pancreatic islet cell protective agent upon pancreatic islet transplantation comprises a compound exhibiting NCX inhibitory activity or its pharmaceutically acceptable salt.COPYRIGHT: (C)2012,JPO&INPIT【課題】糖尿病治療における膵島移植の際の膵島採取時ならびに移植膵島障害を抑制し、膵島の生着を向上させることが可能な、新たな膵島細胞保護剤を提供すること。また、膵島細胞保護剤を、ドナー膵臓もしくはドナーから採取した膵島に添加し、添加後の膵島を糖尿病患者に移植する工程を含む、膵島移植後の膵島細胞の障害を抑制する方法を提供すること。【解決手段】NCX阻害活性を示す化合物又はその医薬上許容される塩を含有する、膵島移植時の膵島細胞保護剤。【選択図】図3
