A pharmaceutical composition comprising a compound of formula 1 chemistry chemdraw filechemistry mol filewherein:n is 1 or 2R1 is hydrogen, C1-C4-alkyl, halogen, OH, or &mdashO&mdashC1-C4-alkylR2 is hydrogen, C1-C4-alkyl, halogen, OH, or &mdashO&mdashC1-C4-alkylR3 is hydrogen, C1-C4-alkyl, OH, halogen, &mdashO&mdashC1-C4-alkyl, &mdashO&mdashC1-C4-alkylene-COOH, or &mdashO&mdashC1-C4-alkylene-CO&mdashO&mdashC1-C4-alkyl, oran acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof anda pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).