UNIVERSITY OF MARYLAND, BALTIMORE; LLC;BIOGEN CHESAPEAKE;BIOGEN CHESAPEAKE, LLC;THE USA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人:
SIMARD, J., MARC,JACOBSON, SVEN
申请号：
CA2988417
公开号：
CA2988417A1
申请日:
2016.05.25
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Embodiments of the disclosure encompass methods and/or compositions for ameliorating or preventing intimal damage caused by mechanical stimulation of endothelial cells. The damage may be caused by use of a device within an artery, vein, or capillary of an individual, such as to remove a thrombus, an embolus or an atherosclerotic plaque in the vessel. Treatment and prevention embodiments concern therapeutically effective amounts of one or more antagonists of the SUR1- TRPM4 channel that is upregulated upon the mechanical stimulation.
