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PYRAZOLE DERIVATIVES
专利权人:
发明人:
申请号:
HK14105124.2
公开号:
HK1191862A
申请日:
2014.05.30
申请国别(地区):
HK
年份:
2014
代理人:
摘要:
The invention relates to compounds of formula wherein R1 is hydrogen or phenyl, optionally substitutes by halogen, CN or lower alkoxy or lower alkoxy substituted by halogen R2 is hydrogen or lower alkyl R3 is hydrogen or lower alkyl or is phenyl optionally substituted by one or more substituents, selected from halogen, cyano or lower alkoxy substituted by halogen, or is pyridinyl, optionally substituted by halogen or lower alkyl substituted by halogen, or is pyrimidinyl, optionally substituted by lower alkyl substituted by halogen, or is pyrazinyl, optionally substituted by halogen, cyano or lower alkyl substituted by halogen R4 is hydrogen, lower alkyl or phenyl Z is a bond, -CH2- or -O- or to a pharmaceutically suitable acid addition salt thereof. It has now been found that the compounds of formulas IA and IB have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinsons disease, neurodegenerative disorders such as Alzheimers disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.La présente invention concerne des composés de formule dans laquelle R1 est un atome dhydrogène ou un groupe phényle, facultativement substitué par un atome dhalogène, un groupe CN ou un groupe alcoxy inférieur ou un groupe alcoxy inférieur substitué par un atome dhalogène R2 est un atome dhydrogène ou un groupe alkyle inférieur R3 est un atome dhydrogène ou un groupe alkyle inférieur ou est un groupe phényle facultativemen
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