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2-OXA-5-AZABICYCLO [2.2.1] HEPTAN-3-YL DERIVATIVES
专利权人:
发明人:
申请号:
HK17106552.8
公开号:
HK1232869A
申请日:
2017.06.30
申请国别(地区):
HK
年份:
2018
代理人:
摘要:
The present invention relates to compounds of formula (I), wherein L is a bond, -C(O)NH-, -NHC(O)-, -CH2NHC(O)-, CH2C(O)NH-, -CH2NH-, -NH- or -NHC(O)NH- R1 is hydrogen, lower alkyl, halogen, lower alkoxy-alkyl, lower alkoxy substituted by halogen, lower alkyl substituted by halogen or is phenyl or heteroaryl selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl or pyrazolyl, and wherein phenyl and heteroaryl are optionally substituted by one, two or three substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cycloalkyl or O-CH2-cycloalkyl or to a pharmaceutically suitable acid addition salt thereof, to all racemic mixtures, all their corresponding enantiomers and/or optical isomers, which may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinsons disease, neurodegenerative disorders, Alzheimers disease, epilepsy, migraine, hypertension, substance abuse, metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.La présente invention concerne des composés de formule (I), dans laquelle L est une liaison, -C (O) NH -, -NHC (O) -, -CH2NHC(O)-, CH2C(O)NH-, -CH2NH-, -NH-ou-NHC (O) NH - R1 est hydrogène, alkyle inférieur, halogène, alcoxy-alkyle inférieur, alcoxy inférieur substitué par halogène, alkyle inférieur substitué par halogène ou est un groupe phényle ou hétéroaryle choisi dans le groupe constitué par pyridinyle, pyrimidinyle, pyrazinyle ou pyrazolyle, et dans laquelle le phényle et lhétéroaryle sont éventuellement substitués par un, deux ou trois substituants chois
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