A compound of structure (I) <；CHEM>； wherein R<；1>； and R<；2>； are each, independently, hydrogen or -CO(CR<；3>；R<；4>；)b(CR<；5>；R<；6>；)dCR<；7>；R<；8>；R<；9>； ； R<；3>； and R<；4>； are each, independently, hydrogen, alkyl, alkenyl, alkynyl, trifluoromethyl, or -F； R<；5>； and R<；6>； are each, independently, hydrogen, alkyl, alkenyl, alkynyl, -(CR<；3>；R<；4>；)fOR<；10>；, -CF3, -F, or -CO2R<；11>；, or R<；5>； and R<；6>； may be taken together to form X or a cycloalkyl ring that is optionally mono-, di-, or tri-substituted with -(CR<；3>；R<；4>；)fOR<；10>；； R<；7>； is hydrogen, alkyl, alkenyl, alkynyl, -(CR<；3>；R<；4>；)fOR<；10>；, -CF3, -F, or -CO2R<；11>；； R<；8>； and R<；9>； are each, independently, hydrogen, alkyl, alkenyl, alkynyl, -(CR<；3>；R<；4>；)fOR<；10>；, -CF3, -F, or -CO2R<；11>；, or R<；8>； and R<；9>； may be taken together to form X or a cycloalkyl ring that is optionally mono-, di-, or tri-substituted with -(CR<；3>；R<；4>；)fOR<；10>；； R<；10>； is hydrogen, alkyl, alkenyl, alkynyl, tri-(alkyl)silyl, tri-(alkyl)silylethyl, triphenylmethyl, benzyl, alkoxymethyl, tri-(alkyl)silylethoxymethyl, chloroethyl, or tetrahydropyranyl； R<；11>； is hydrogen, alkyl, alkenyl, alkynyl, or phenylalkyl； X is 5-(2,2-dialkyl)Ä1,3Üdioxanyl, 5-(2,2-dicycloalkyl)Ä1,3Üdioxanyl, 4-(2,2-dialkyl)Ä1,3Ü-dioxanyl, 4-(2,2-dicycloalkyl)Ä1,3Üdioxanyl, 4-(2,2-dialkyl)Ä1,3Üdioxalanyl, or 4-(2,2-dicycloalkyl)Ä1,3Üdioxalanyl； b = 0-6； d = 0-6； and f = 0-6 with the proviso that R<；1>； and R<；2>； are both not hydrogen and further provided that either R<；1>； or R<；2>； contains at least one -(CR<；3>；R<；4>；)fOR<；10>；, X, or -(CR<；3>；R<；4>；)fOR<；10>； substituted cycloalkyl group, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitum
