THE INVENTION RELATES TO AN ASSOCIATION INCLUDING AT LEAST: A MC1-R RECEPTOR INHIBITOR; A TYROSINASE INHIBITOR DERIVED FROM VITAMIN C; AN INHIBITOR OF THE TRANSFER OF MELANOSOMES TO THE KERATINOCYTES; THE INVENTION ALSO RELATES TO THE USE THEREOF IN COSMETICS AND DERMATOLOGY FOR PREPARING WHITENING AND/OR BLEACHING DEPIGMENTATION COMPOSITIONS.