COE JOTHAM WADSWORTH,DEHNHARDT CHRISTOPH MARTIN,JONES PETER,SABNIS YOGESH ANIL,STROHBACH JOSEPH WALTER,WAKENHUT FLORIAN MICHEL,WHITLOCK GAVIN ALISTAIR
申请号：
SV2016005318
公开号：
SV2016005318A
申请日:
2016.11.11
申请国别(地区):
SV
年份:
2017
代理人:
摘要：
A compound having the structure: (see formula)； or one of its Salts farmac u00c3 u2030uticamente acceptable or a solvate of the compound or Salt acceptable farmac u00c3 u2030uticamente farmac u00c3 u2030uticamente acceptable, in which a and a 'are, independently, c or n, which may or may not be replaced or And be replaced with Halo or c1-c6 alkyl； R and R0 are selected independently,The group consisting of H, alkyl Hydroxy (C1 - C6 C1 - C6 alkyl, phenyl alkyl C1 - C6) and - (CH2) n - W, where W is cycloalkyl C3 - C8, phenyl, naphthyl, heteroaryl or "5 * 6 members heteroc u00c3 ufffdclico containing 1 - 3 of u00c3 ufffdtomos n, s and / or S02, - - - - nhso2 R ', R' - Nr and Sr 502 - R ', where r' and R ' Are independently alkyl, cycloalkyl, 01 - 06 0 C3, C8, etc.Where each of these alkyl, cycloalkyl, heteroc u00c3 ufffdclico heteroaryl phenyl, naphthyl, or can not be replaced or can be substituted with phenyl heteroaryl, etc.Or R and R0 and the u00c3 ufffdtomo n est u00c3 ufffdn United to form a ring heteroc u00c3 ufffdclico monoc u00c3 ufffdclico or bic u00c3 ufffdclico which can not be replaced or can be replaced with (a) Halo heteroaryl alkyl, Hydroxy, alkoxy, C1 C1 - C6, C8, etc. or (b) - (CH2) n - W, where W is cycloalkyl C3 - C8, FENI What, etc.； r1 is H, or cyano Halo； R2 and R2 'are independently h, c1-c6 alkyl, cyano, c1-c6 alkoxy alkyl, cycloalkyl or C1 - C6 Uncle C3 - C8 alkoxy or alkyl, cycloalkyl, optionally substituted with one or more est u00c3 ufffd u00c3 ufffdtomos of fl u00c3 u0161or； X is a link with co -, -, -, - SO2 -, - or - sonh M - (CH2)； R3 is H, c1-c4 alkyl, phenyl, naphthyl,Heteroaryl 5 * 6 members "or heteroc u00c3 ufffdclico containing 1 - 3 u00c3 ufffdtomos n, 5 members or a heteroaryl heteroc u00c3 ufffdclico, etc.(c) or 2 u00c3 ufffdtomos or s and 0 - 2 u00c3 ufffdtomos N； where each phenyl, naphthyl, or optionally substituted heteroaryl 25 heteroc u00c3 ufffdclico est u00c3 ufffd alkyl Substituent, - 1 and - 1 - 4 and / or R
