КИМ Йонг Ил (KR),ЧО Дзунг Хиун (KR),ЧОЙ Юн Йоунг (KR),ЧОЙ Йоунг Кеун (KR),ПАРК Дзае Хиун (KR),ВОО Дзонг Соо (KR)
申请号：
RU2015111546
公开号：
RU2015111546A
申请日:
2013.08.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The two-layer composite tableted composition comprising: (a) a first layer comprising irbesartan or a pharmaceutically acceptable salt thereof and (b) a second layer comprising atorvastatin or a pharmaceutically acceptable salt and magnesium carbonate in a weight ratio of from 1: 4 to 1: 5.2. The two-layer composite structure of claim tableted. 1, in which atorvastatin is in forme.3 anhydride. Two-layer composite tableted composition according to Claim. 1, wherein the irbesartan or a pharmaceutically acceptable salt thereof is contained in an amount of from 8 mg to 600 mg per unit sostava.4. Two-layer composite tableted composition according to Claim. 1, wherein atorvastatin or a pharmaceutically acceptable salt thereof is contained in an amount of from 1 mg to 80 mg per unit sostava.5. Two-layer composite tableted composition according to Claim. 1, wherein the first layer further comprises a pharmaceutically acceptable additive selected from the group consisting of an aqueous diluent, binder, disintegrant, lubricant, surfactant and smesi.6. Two-layer composite tableted composition according to Claim. 1, wherein the second layer further comprises a pharmaceutically acceptable additive selected from the group consisting of an aqueous diluent, binder, disintegrant, lubricant and smesi.7. . A method of producing two-layer composite tablet composition according to claim 1, which comprises the following steps: 1) forming granules comprising irbesartan or a pharmaceutically acceptable salt thereof, and 2) forming granules comprising atorvastatin or a pharmaceutically acceptable salt and magnesium carbonate in a weight ratio of 1 : 4 to 1: 5 and 3) compression1. Двухслойный композиционный таблетированный состав, содержащий: (а) первый слой, содержащий ирбесартан или его фармацевтически приемлемую соль и (b) второй слой, содержащий аторвастатин или его фармацевтически приемлемую соль и карбонат магния в массовом отношении от 1:4 до 1:5.2. Двухслойный композиционный табле
