DI TOMASO, Emmanuelle,FRITSCH, Christine,GERMA, Marie-Caroline,MASSACESI, Cristian,SCHNELL, Christian Rene,TAVORATH, Ranjana
申请号：
TN2016000179
公开号：
TN2016000179A1
申请日:
2014.12.03
申请国别(地区):
TN
年份:
2017
代理人:
摘要：
The present invention relates to methods of treating or preventing a proliferative disease in a patient in need thereof by orally administering a therapeutically effective amount of an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor compound of formula (1) or a pharmaceutically acceptable sait thereof for at least two five-consecutive day cycle, wherein said compound is not administered to the patient for a period of about two days to about three days between said five-consecutive day cycles； the use of said compound of formula (1) or a pharmaceutically acceptable sait thereof for the manufacture of a medicament for treating or preventing a proliferative disease administered in accordance with said dosage regimen； therapeutic regimen comprising administration of said compound of formula (1) or a pharmaceutically acceptable sait thereof in accordance with said dosage regimen； and related pharmaceutical compositions and packages thereof.
