NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
发明人:
申请号：
EP09708976.7
公开号：
EP2248894B1
申请日:
2009.02.04
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention relates to a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1, or a nucleotide sequence the same or substantially the same as a partial nucleotide sequence thereof containing at least one HRE consensus sequence, which transiently has a transcription promoting activity in a vascular endothelial cell-specific manner in a hypoxic state, or a vector containing a promoter containing the DNA, and the like. The prophylaxis and/or treatment, as well as diagnosis of acute ischemic diseases are enabled by connecting a prophylactic and/or therapeutic gene or a reporter gene to the downstream of the vector and administering same to mammals. The present invention can provide a means of detecting, in the initial stages of onset, acute ischemic diseases such as myocardial infarction and the like. In addition, the present invention can provide a drug delivery system capable of efficient delivery of a medicament to the lesion of the disease, using which to provide a novel and effective prophylactic and/or therapeutic means for acute ischemic diseases.
