Cunningham, Mark R.,Swencki-Underwood, Bethany,Tang, Yi,Yan, Li
申请号：
AU2009296937
公开号：
AU2009296937B2
申请日:
2009.08.19
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention provides antibodies immunospecifϊc for human CD 147 capable of blocking bioactivity of CD 147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD 147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
