CUNNINGHAM, MARK, R.,SWENCKI-UNDERWOOD, BETHANY,TANG, YI,YAN, LI
申请号：
EP09816663
公开号：
EP2334330A4
申请日:
2009.08.19
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
