The invention relates to a composition comprising: i) one or more of uridine and cytidine, or salts, phosphates, acyl derivatives or esters thereof ii) a lipid fraction comprising at least one of docosahexaenoic acid (22:6 DHA), eicosapentaenoic acid (20:5 EPA) and docosapentaenoic acid (22:5 DPA), or esters thereof, in which the lipid fraction comprises less than 2 weight% of ±-linolenic acid (ALA), calculated on the weight of all fatty acids iii) choline, or salts or esters thereof for use in the prevention or treatment of neurotrauma, traumatic brain injury, cerebral palsy and spinal cord injury.