The invention relates to a composition comprising:i) one or more of uridine and cytidine, or salts, phosphates, acyl derivatives or esters thereof;ii) a lipid fraction comprising at least one of docosahexaenoic acid (22:6; DHA), eicosapentaenoic acid (20:5; EPA) and docosapentaenoic acid (22:5; DPA), or esters thereof, in which the lipid fraction comprises less than 2 weight% of α-linolenic acid (ALA), calculated on the weight of all fatty acids;iii) choline, or salts or esters thereof;for use in the prevention or treatment of neurotrauma, traumatic brain injury, cerebral palsy and spinal cord injury.